个人简介

杨泽宙，宁夏中宁人。2018年6月毕业于西北农林科技大学化学与药学院应用化学专业，获理学学士学位。2021年6月毕业于西南大学化学化工学院分析化学专业，获理学硕士学位，导师为袁若教授，主要从事新型纳米材料协同核酸放大策略构建荧光生物传感器用于肿瘤标志物的超灵敏检测与细胞成像。2026年6月毕业于北京大学化学与分子工程学院物理化学专业，获理学博士学位，导师为郭雪峰教授，主要从事硅基石墨烯单分子器件制备，利用单分子器件的电学信号原位实时跟踪单分子行为/单个事件的动力学过程，揭示分子的本征物性以及反应路径的可视化。部分研究成果已经发表于J. Am. Chem. Soc., Angew. Chem. Int. Ed., Chem. Sci., Anal. Chem., Biosens. Bioelectron., Chem. Commun.等期刊。

代表性成果

1. Zezhou Yang+, Boyu Wang+, Xinmiao Xie+, Jianning Zhang+, Panfeng Chuai, Jie Hao, Wenlong Cai, Zhiheng Yang, Chunyan Gao, Fanyang Mo*, Zujin Shi*, Jinying Wang*, Chuancheng Jia*, Xuefeng Guo*. Orbital-resolved stepwise single-electron capture dynamics in a single fullerene. J. Am. Chem. Soc. 2025, 147, 31791–31799.

2. Wenlong Cai+, Xinmiao Xie+, Zezhou Yang+, Xuefeng Guo*.Stereochemistry at the single-molecule level: From monitoring to regulation, Angew. Chem. Int. Ed. 2025, e202504558.

3. Zezhou Yang, Xin Peng, Peng Yang, Ying Zhuo, Yaqin Chai, Wenbin Liang*, Ruo Yuan*. A Janus 3D DNA nanomachine for simultaneous and sensitive fluorescent detection and imaging of dual microRNAs in cancer cells. Chem. Sci. 2020, 11, 8482–8488.

4. Zezhou Yang, Jie Zhou, Fang Liu, Yaqin Chai, Pu Zhang*,  Ruo Yuan*. CsPbBr₃ perovskite quantum dots encapsulated by a polymer matrix for ultrasensitive dynamic imaging of intracellular microRNA. Anal. Chem. 2024, 96, 10738–10747.

5. Zezhou Yang, Yu Guo, Jie Zhou, Fang Liu, Wenbin Liang, Yaqin Chai, Zhaohui Li*, Ruo Yuan*. Ultrasensitive fluorescence detection and imaging of microRNA in cells based on a hyperbranched RCA-assisted multiposition SDR signal amplification strategy. Anal. Chem. 2022, 94, 16237–16245.

6. Zezhou Yang, Zhibin Wen, Xin Peng, Yaqin Chai, Wenbin Liang*, Ruo Yuan*. A novel fluorescent assay for the ultrasensitive detection of miRNA-21 with the use of G-quadruplex structures as an immobilization material for a signal indicator. Chem. Commun. 2019, 55, 6453–6456.

7. Fang Liu, Zezhou Yang, Jie Zhou, Yaqin Chai, Ruo Yuan*, Shaping Wei.* Ultrasensitive fluorescence detection and accurate colocalization visualization of dual-miRNAs in cancer cells based on the conjugated chain reaction of multifunctional pentagon DNA nanostructures. Anal. Chem. 2022, 25, 9026–9032.

8. Jie Zhou, Xin Peng,  Zezhou Yang, Ying Zhuo, Wenbin Liang, Ruo Yuan*, Yaqin Chai*. Discrimination between cancer cells and DNA-damaged cells: Pre-miRNA region recognition based on hyperbranched hybrid chain reaction amplification for simultaneous sensitive detection and imaging of miRNA and Pre-miRNA. Anal. Chem. 2022, 94, 9911–9918.

9. Zhaopeng Chen, Peng Yang, Zezhou Yang, Yaqin Chai, Ruo Yuan, Ying Zhuo, Wenbin Liang*. One-step digital droplet auto-catalytic nucleic acid amplification with high-throughput fluorescence imaging and droplet tracking computation. Anal. Chem. 2022, 94, 9166–9175.

10. Yue Zhang, Yifei Chen, Yamin Nie, Zezhou Yang, Ruo Yuan*, Haijun Wang*, Yaqin Chai*. Highly efficient aggregation-inducedelectrochemiluminescence of Al(III)-cbatpymetal-organic gels obtained by ultrarapid self-assembly for a biosensing application. Anal. Chem. 2022, 94, 12196–12203.

11. Xin Peng, Zezhou Yang, Peng Yang, Yaqin Chai, Wenbin Liang,  Zhaohui Li*, Ruo Yuan*. Rapid self-disassembly of DNA diblock copolymer micelles via target induced hydrophilic hydrophobic regulation for sensitive miRNA detection. Chem. Commun. 2020, 56, 10215–10218.

12. Zhibin Wen, Xin Peng, Zezhou Yang, Ying Zhuo, Yaqin Chai, Wenbin Liang*, Ruo Yuan*. A dynamic 3D DNA nanostructure based on silicon-supported lipid bilayers:a highly efficient DNA nanomachine for rapid and sensitive sensing. Chem. Commun. 2019, 55, 13414–13417.