个人简介

2009年7月于清华大学化学系获理学博士学位。现为陕西师范大学化学化工学院教授，分析化学/化学生物学专业博士生导师，应用表面与胶体化学教育部重点实验室副主任，陕西省生命分析化学重点实验室副主任。兼任陕西省化学会常务理事、副秘书长，陕西省中学化学竞赛及教育工作委员会副主任。2015年度“陕西省青年科技新星”；2016年获得国家基金委“优秀青年科学基金”资助；2019年获评陕西省百名优秀青年科技新星；2020年获陕西青年科技奖；担任Wiley出版社ChemistrySelect等期刊编委。主要研究兴趣为：（1）生化分析与分子诊断；（2）功能材料表界面传感；（3）单分子与单颗粒分析。先后主持国家自然科学基金等省部级以上项目10余项，获陕西省及河北省科学技术奖励3项。作为通讯作者在Angew. Chem. Int. Ed., Adv. Mater., Nucleic Acids Res., Nano Lett., Anal. Chem.等发表论文100余篇。

因科研工作需要，课题组常年招聘博士后，特别优秀者可直接申报副教授岗位，陕师大正处于快速发展时期，人才引进力度大，待遇优厚，具体情况可邮件联系。热忱欢迎从事微流控芯片分析、功能材料与器件、分子诊断、纳米生物技术等相关领域的同仁加盟合作。

代表性成果

Chao Lei, Wenjiao Fan, Jingjing Shi, Zhaowei Tian, Xinrui Duan*, Chenghui Liu*. Persistent Chemiluminescence-Enabled Digital Bead Counting for Quantifying Attomolar MicroRNAs. Nano Lett., 2025, DOI: 10.1021/acs.nanolett.5c00838.

Xinrui Fei, Cao Lei, Wei Ren, Chenghui Liu*. 'Splice-at-will' Cas12a crRNA engineering enabled direct quantification of ultrashort RNAs. Nucleic Acids Res., 2025, 53, gkaf002.

Xinrong Yan^†, Qingyuan Wang^†, Peiru Yang^†, Yuan Liu, Bin Liu, Tian Wang, Dehui Qiu, Shijiong Wei, Desheng Chen, Jun Zhou,* Chenghui Liu,* and Xiaobo Zhang*. Amplification Bias-Free Sequence-Generic Exponential Amplification Reaction. Anal. Chem., 2025, 97, 2308-2317.

Yuanyuan Dong, Wei Ren*, Yuanyuan Sun, Xinrui Duan, Chenghui Liu*. Aggregation-Augmented Magnetism of Lanthanide-Doped Nanoparticles and Enabling Magnetic Levitation-Based Exosome Sensing. Adv. Mater., 2024, 36, 2407013.

Yan Qi*, Junyue Sun, Shan Wang, Wei Ren, and Chenghui Liu*. Mix-and-Read Digital MicroRNA Analysis Based on Flow Cytometric Counting of Target-Clicked Nanobead Dimer. Anal. Chem., 2024, 96, 13734-13741.

Dailu Jia, Chao Lei, Wei Ren,* Chenghui Liu*. Augmented Fluorescence Signaling on a Single BaTiO3 Microbead Optical Booster toward High-Sensitive Biosensing. Anal. Chem., 2024, 96, 8560-8565.

Shuang Mu, Zhaowei Tian, Wei Ren*, Chenghui Liu*. Laser-Induced Thermophoretic SERS Enhancement on Paper for Facile Pesticide and Nanoplastic Sensing. Anal. Chem., 2024, 96, 19840-19846.

Wenjiao Fan, Yuanyuan Dong, Wei Ren*, Chenghui Liu*. Single microentity analysis-based ultrasensitive bioassays: recent advances, applications, and perspectives. Trends Anal. Chem., 2023, 162, 117035.

Wenjiao Fan, Wei Ren*, Dailu Jia; Jingjing Shi, Chenghui Liu*. A Digital-Like Enzyme Inhibition Mechanism-Based Strategy for the Digital Sensing of Heparin-Specific Biomarkers. Anal. Chem., 2023, 95, 13690-13697.

Desheng Chen^†, Xiaobo Zhang^†, Liping Zhu, Chenghui Liu*, Zhengping Li*. All on Size-Coded Single Bead Set: Modular Enrich-Amplify-Amplify Strategy for Attomolar Level Multi-Immunoassay. Chem. Sci., 2022, 13, 3501-3506.

Wenjiao Fan, Pihua Han, Qinya Feng, Yuanyuan Sun, Wei Ren, Thomas Lawson, and Chenghui Liu*. Nucleic Acid Substrate-Independent DNA Polymerization on the Exosome Membrane: A Mechanism Study and Application in Exosome Analysis. Anal. Chem., 2022, 94, 2172-2179.

Lijun Zhang, Wenjiao Fan, Dailu Jia, Qinya Feng, Wei Ren, Chenghui Liu*. Microchamber-Free Digital Flow Cytometric Analysis of T4 Polynucleotide Kinase Phosphatase Based on Single Enzyme-to-Single Bead Space-Confined Reaction. Anal. Chem., 2021, 93, 14828-14836.

Xiaohui Lu^†, Chen Hu^†, Dailu Jia, Wenjiao Fan, Wei Ren*, Chenghui Liu*. Amplification-Free and Mix-and-Read Analysis of Multiplexed MicroRNAs on a Single Plasmonic Microbead. Nano Lett., 2021, 21, 6718-6724.

Yan Qi, Yuqing Zhai, Wenjiao Fan, Wei Ren, Zhengping Li, Chenghui Liu*. Click Chemistry-Actuated Digital DNA Walker Confined on a Single Particle toward the Absolute MicroRNA Quantification. Anal. Chem., 2021, 93, 1620-1626.

Gaoting Wang, Weimin Tian, Xiaoling Liu*, Wei Ren, Chenghui Liu*. A new CRISPR-derived microRNA sensing mechanism based on Cas12a self-powered and rolling circle transcription (RCT)-unleashed real-time crRNA recruiting. Anal. Chem., 2020, 92, 6702-6708.

Xiaohui Lu, Wei Ren, Chen Hu, Chenghui Liu*, Zhengping Li*. Plasmon-Enhanced SERS Mapping Concentrated on a Single Bead for the Ultrasensitive and Multiplexed Immunoassay. Anal. Chem., 2020, 92, 12387-12393.

Hui Tian, Wenhan Zhao, Xiaolong Liu, Chenghui Liu*, Niancai Peng*. An integrated single microbead-arrayed μ-fluidic platform for the automated detection of multiplexed biomarkers. ACS Sens., 2020, 5, 798-806.

Ya Li^†, Dailu Jia^†, Wei Ren*, Feng Shi, Chenghui Liu*. A Versatile Photoinduced Electron Transfer-Based Upconversion Fluorescent Biosensing Platform for the Detection of Disease Biomarkers and Nerve Agent. Adv. Funct. Mater., 2019, 29, 1903191.

Liping Zhu, Desheng Chen, Xiaohui Lu, Yan Qi, Pan He, Chenghui Liu,* Zhengping Li. An Ultrasensitive Flow Cytometric Immunoassay Based on Bead Surface-Initiated Template-Free DNA Extension. Chem. Sci., 2018, 9, 6605-6613.

Wenjiao Fan, Yan Qi, Liying Qiu, Pan He, Chenghui Liu,* Zhengping Li. Click Chemical Ligation-Initiated On-Bead DNA Polymerization for the Sensitive Flow Cytometric Detection of 3´-Terminal 2´-O-Methylated Plant MicroRNA. Anal. Chem., 2018, 90, 5390-5397.

Yueying Sun, Yuanyuan Sun, Weimin Tian, Chenghui Liu,* Kejian Gao, Zhengping Li.* A novel restriction endonuclease GlaI for rapid and highly sensitive detection of DNA methylation coupled with isothermal exponential amplification reaction. Chem. Sci., 2018, 9, 1344-1351.